Last year I was looking for a cloud hosting solution and I decided on Pydio and even wrote up a install guide (http://allandynes.com/2015/08/was-searching-for-a-cloud-provider/). Some time has gone by and I’ve updated those instructions for the latest version of Pydio (6.4.1 currently) and also to be a purely 64-bit install (PHP 7 x64, MySql 5.7 x64, etc). The overall effect on a Server 2012 / IIS 8.5 install is quicker performance and less issues with large data syncs. I’ve also updated it to include information on SMB shares so you can access your existing Windows based file server from your cloud server so you are not duplicating files. Here is the new install guide:

Installing-Pydio-on-Windows-Server-2012-R2-Pure-64-bit-With-Samba